Approximate dose equivalencies. Always individualize and titrate clinically.
| Methylphenidate (total daily) | Mixed Amphetamine Salts (Adderall) | Lisdexamfetamine (Vyvanse) | Dexmethylphenidate (Focalin) |
|---|---|---|---|
| 10 mg | 5 mg | ~20–30 mg | 5 mg |
| 20 mg | 10 mg | ~30–40 mg | 10 mg |
| 30 mg | 15 mg | ~50 mg | 15 mg |
| 40 mg | 20 mg | ~60–70 mg | 20 mg |
| 54–60 mg | 27–30 mg | ~70 mg | 27–30 mg |
Based on approximate 2:1 methylphenidate:amphetamine ratio and common clinical references (AACAP, UpToDate-style guides). Lisdexamfetamine conversions are rough. Not a substitute for clinical judgment. Titrate to response and tolerability.